In this project we seek: hereditary tumors of the nervous system in addition the eight such diseases recognized; to add to the clinical description and natural history of these diseases; to suggest methods for early diagnosis; evaluate present modes of treatment; and develop methods for pre-clinical detection and screening. Presently we are evaluating the usefulness of serum nerve growth factor as a screening device for those at risk for central neurofibromatosis and serum norephinephrine as a screening device in the von Hippel-Lindau syndrome and computerized axial tomography as a screening measure in both diseases.